The two central American rivals have squared off 42 times across competitions. El Tri have been the dominant team against their southern rivals, recording 23 wins.
Guatemala have come out on top six times, while 13 ended in draws. Mexico have kept a clean sheet in their last four meeting with Los Chapines, winning their last two games by a 3-0 margin.
Coach Gerardo Martino has a 20-man squad against Guatemala. As many as four players have earned their first callups for the national team and are in contention to start. As this is not a FIFA-recognised game, the players featuring outside of Liga MX will not be able to feature here.